Sam-Ehas been known to treat pain, stiffness and joint swelling; improve mobility; rebuild cartilage and ease symptomsSAMe may also help with depression, a very common diagnosis that can be hard to treat. SAMe appears to be a safe and successful approach for depression relief.The body manufactures SAMe from methionine, an amino acid found in protein-rich foods, and adenosine triphosphate (ATP), an energy-producing compound found in all the body’s cells. The SAMe molecule then donates a piece of itself (a methyl group) to body tissues and organs, providing a critical link in methylation, a chemical reaction that occurs billions of times a second throughout the body. In giving up a part of itself, SAMe promotes cell growth and repair.SAMe also contributes to the formation of key compounds in the brain, including the neurotransmitter dopamine and the mood-enhancer serotonin. In addition, it helps to maintain desirable levels of glutathione, a major antioxidant that protects against cell damage from oxygen molecules called free radicals. Taken as a supplement, SAMe compensates for any deficiencies and encourages the body to run efficiently.Specifically, SAMe may help to:Relieve depression and stress-related blues. Several studies indicate that SAMe eases mild to moderately severe depression. A sweeping review of dozens of small clinical trials (called a “meta-analysis”) testing SAMe for depression concluded that it appears to work as well as the frequently prescribed tricyclic antidepressants (imipramine, amitriptyline, desipramine) in easing depression. Just as importantly, it works faster360 capsules in a heat sealed pouch.