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TOP ANTI- AGING SKIN CARE INGREDIENTSSWISS APPLE STEM CELLSThis active ingredient won the prize in European Innovation “Best Active Ingredient” in 2008. It is a revolutionary technology designed to protect human skin stem cells with the help of stem cells from a rare Swiss apple. The clinical trials conducted by the company who discovered this ingredient showed that 100% of the participants saw a reduction in fine lines and wrinkles after using a solution containing PhytoCellTech Malus Domestica.WHAT ARE SWISS APPLE STEM CELLS?PhytoCellTec Malus Domestica is an award-winning patented liposomal preparation, so containing tiny bubbles made out of the same material as cell membranes, based on the stem cells of a rare Swiss apple called Uttwiler Spätlauber that derives from a seedling planted in the middle of the18th century. Uttwiler Spätlauber is an endangered apple variety that is well-known for its ability to be stored for long periods without shrivelling and thus its longevity potential. The apples are rich in phytonutrients, proteins and long-living cells. A novel technology has now been developed enabling the cultivation of rare and endangered species like Uttwiler Spätlauber. Thanks to this technology, plant stem cells can be obtained and incorporated into skin care products to enhance the longevity of skin cells. Not only does it protect the skin’s own stem cells but has been shown to have excellent age-delaying and anti-wrinkle properties, and is currently one of the most pioneering and exciting ingredients in skin care.THE SCIENCE BEHIND STEM CELLSStem Cells and Longevity Longevity is related to specific cells called stem cells which have a unique growth characteristic. These cells can make identical copies of themselves as well as differentiate (in other words, split) to become separate, specialised cells. Two basic types of stem cells are present in the human body: Embryonic stem cells found in blastocysts (structures found in the human pre-embryonic stage) can grow and differentiate into one of the more than 220 different cell types which make up the human body; Adult stem cells located in some adult tissues can only differentiate into their own or related cell types. These cells act as a repair system for the body but also maintain the normal turnover of regenerative organs such as blood, skin or intestinal tissues. Research on Stem Cells and Applications Currently in medicine, adult stem cells are already used particularly in transplant medicine to treat leukemia and severe burns. In the cosmetic field, scientists are focusing their research on adult stem cells located in the skin. They are studying the potential of this type of cells, their functioning and aging. This research is helping us understand how to protect skin stem cells. Stem Cells in the Human Skin In the human skin, two types of adult stem cells have been identified: Epithelial skin stem cells which are located in the basal layer of the epidermis. Hair bulge stem cells located in the hair follicle. Epidermal or skin stem cells replenish and maintain the balance of cells within the skin tissue and regenerate tissue damages during injury. But with age, the number of skin stem cells decreases and their ability to repair the skin becomes less efficient. Plant Stem Cells to Protect Skin Stem Cells In contrast to human, plant cells are totipotent, meaning that every cell has the ability to regenerate new organs (leaves, flower, seed…) or even the whole plant. Besides, all plant cells can differentiate and become a stem cell. All stem cells, independently of their origin (plant, animal or human) contain specific epigenetic factors whose function is to maintain the self-renewal capacity of stem cells.WHAT DO SWISS APPLE STEM CELLS DO? ANTI-WRINKLE EFFECT ON CROWS FEETThe anti-wrinkle effect of Malus Domestica was evaluated in a study with 20 volunteers aged from 37 to 64. An emulsion containing 2 % of PhytoCellTec™ Malus Domestica was applied twice daily for 28 days to the crow’s feet. Wrinkle depth was determined by means of PRIMOS (phase-shifting rapid in vivo measurement of skin). Results showed a significant and visible decrease in wrinkle depth for 100 % of the subjects.DEPTH OF WRINKLES USING 2.5% APPLE STEM CELL EMULSION DAY 0 AFTER 28 DAYS (2.5% APPLE STEM CELL EMULSION) SAW A REDUCTION OF WRINKLE DEPTH OF 15%AGE -DELAYING EFFECT ON HAIR FOLLICLES OF APPLE STEM CELLSHair follicles are mini organs that represent a natural combination of epidermal and melanocyte (cells in the bottom layer of the skin) stem cells. The follicles can be maintained in a growth medium where they elongate until about day 14. Then the follicle cells gradually become senescent or undergo apoptosis – effectively they deteriorate and start to die - which is caused by the lack of blood circulation. Isolated hair follicles represent a good test model to analyse actives ingredients, such as Malus Domestica, that can delay the cell deterioration and death process. Isolated human hair follicles were incubated with Malus Domestica extract. Addition of 0.2 % of this extract was found to slightly but clearly postpone deterioration and necrosis: follicles kept in presence of the Malus Domestica stem cell extract continued to elongate until day 18, whereas the control follicles started to shrink after day 14. Change in hair follicle length compared to Day 14 in %MAINTENANCE OF STEM CELL GROWTHAn in vitro test was conducted on blood stem cells with Malus Domestica stem cell extract. The influence of Malus Domestica stem cell extract on blood stem cell growth was evaluated by counting the cell number after incubation. Results showed that Malus Domestica stem cell extract has a positive effect on stem cell growth thus maintaining the growth and the proliferative activity of stem cells. Increase in Cell Growth ActivityPROTECTION AGAINST UV RADIATIONAnother test was conducted on blood stem cells. The protective effect against UV damage of Malus Domestica stem cell extract was evaluated by scientific analysis. Cells were incubated with different concentrations of Malus Domestica stem cell extract for 24h and were then exposed to UV radiation. The analysis, which measures the number of cells still living and therefore the damage from UV, was performed 48 hours after UV radiation. Results showed the capacity of Malus Domestica to protect cells from UV damage even at low concentrations.What Phytessence Wakame offers you is a protective barrier between your hyaluronic acid, and the enzymes that cause this firming substance to break down.Wakame Cell Culture Extract: Anatural, sustainable, bioactive derived from cultured Wakame. This unique ingredient was designed specifically to reduce the generation of reactive oxygen species produced by our cells. Efficacy studies reveal that ACB Wakame Bioferment Advanced reduces ROS production better than Vitamin C. As an added benefit, this product is also capable if increasing collagen synthesis to provide additional anti-aging benefits.A unique active derived from the depths of the ocean. Developed from cultured wakame cells, Wakame Cell Culture Extract Advanced can increase oxygen consumption, while reducing the formation of reactive oxygen species (ROS) to increase mitochondrial efficiency. This product targets the mitochondria, which has been shown to play a vital role in apoptosis in order to contribute to the longevity of cells and minimize damage at a cellular level.With regular use your levels of hyaluronic acid will gradually increase to the amounts normally found in a much younger person. Clinical trials have proven this! Also has the ability to protect your skin from the harmful UV rays of the sun along with everyday environmental pollution. Additionally, the algae’s ability to moisturize deep down into the skin, means that it’s going to prevent the signs of aging and provide an overall boost to your health.A highly concentrated, fast penetrating serum withDMAE (organic compound) and MSM (naturally occurring nutrient) actingin synergy gives you the perfect day serum for radiant healthy skin. With natural ingredients like spirulina, black willow bark extract, aloe juice and neem oil, you have a perfect organic anti-aging barrier, with wrinkle protection benefits to apply on a daily basis.Contains Highly Nutritious Super-Foods For Your SkinMSM- Naturally occurring nutrient found in plants- Helps the skin to heal itself- Anti-inflammatory and anti-microbial properties- Stimulates the formation of collagen and elastin- Prevents cross-linking between cells, the primary cause of wrinkles and scar tissue.DMAE- Widely recommended by Dr. Nicholas Perricone, publisher of the top-selling book, The Wrinkle Cure, in which he promotes supplementing with DMAE as a treatment for reducing wrinkles.Organic Aloe Juice- Improves the skin's natural firmness- Non-greasy moisturizer- Helps new skin cell regeneration - Natural healing and anti-inflammatory propertiesMeadowfoam Seed Oil- Non-greasy moisturizer-Forms a moisture barrier, preventing moisture loss.- Protects the skin from the Sun's UV rays - Highly stable oil, extends the shelf-life of other organic ingredientsSpirulina Algae Extract- Rich withprotein, vitamins, minerals and fatty acids- You could consider spirulina as highly nutritious super-food for your skin-Antioxidants Vitamins C, E and beta carotene attack free radicalsthroughoutthe body that would normally cause havoc on cells and organs increasing the aging effectBlack Willow Bark Extract-The Greek 'grand-father of medicine' Hippocrates tought about black willow bark in 400 B.C.- Anti-microbial, anti-inflammatory astringent-Aids skin regeneration on a cellular level - Contains salicin that prevents skin problems Hyaluronic acid - Curb premature aging - Increase skin hydration - keep skin moist and smooth - boost skin
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